Biological role of anti-aging protein klotho

Author: zdvg

August undefined, 2024

WebThe long non-coding RNAs (lncRNA) play an important role in several biological processes including some renal diseases. Nevertheless, little is known on lncRNA that are expressed in healthy kidney and involved in renal cell homeostasis and development, and even less is known about lncRNA involved in the maintenance of human adult renal stem/progenitor … WebOct 20, 2024 · Klotho is an anti-aging protein with several therapeutic roles in the pathophysiology of different organs, such as the skeletal muscle and kidneys. Available evidence suggests that exercise ...

Actions of Klotho on hippocampal neuronal cells - ScienceDirect

WebJun 15, 2024 · Klotho is a membrane-bound or soluble antiaging protein, whose protective activity is essential for a proper function of many organs. In 1997, an accidental insertion … WebKlotho is an antagonist of the Wnt signaling pathway, and chronic Wnt stimulation can lead to stem cell depletion and aging. Klotho inhibition of Wnt signaling can inhibit cancer. The … little amal antwerpen

Is Sleep Associated with the S-Klotho Anti-Aging Protein in …

WebIntroduction. Klotho, the gene encoding the antiaging protein called klotho, was discovered in 1997 when mice developed multiple organ failure and shortened life span … WebThe main spot of Klotho activity is kidney and in the physiological state presumably the most important one. 6 This idea is warranted by the study made on mice with a kidney … WebKlotho is a new anti-aging gene. Genetic mutation of klotho causes multiple premature aging-like phenotypes and strikingly shortens lifespan. Overexpression of the klotho gene in mice suppresses aging and extends lifespan which may involve the mechanism of suppression of insulin signaling and oxidant stress. little amal brighton

Biological Role of Anti-aging Protein Klotho. - Abstract

WebKlotho plays a major role in kidney disease as much of the Klotho protein circulating in the blood is produced in the kidneys. ... Aging is a complex biological process regulated by multiple intrinsic and extrinsic factors such as genetics, epigenetics, environment, lifestyle, and immune response. Aging is often defined as an age-related ... WebKlotho is an aging suppressor protein that is abundant in kidney tissue and Klotho-knockout mice have been shown to develop a syndrome similar to premature aging (30,31). The present study focused on determining the relevance of radiation-induced cellular senescence and the involvement of Klotho. little amal in wiganWebFeb 19, 2024 · Klotho (KL), named after the Greek goddess of destiny who was the spinner of the thread of life, is involved in the aging process and may act as an anti-aging hormone in mammals. The KL gene is located in chromosome 13 in humans. It encodes a transmembrane protein with an extracellular domain, a transmembrane domain, and an … little amal events

"WebSleep and Klotho have both been closely related to the ageing process, both playing a substantial role in the endocrine and immune systems and, thereby, in oxidative stress and chronic inflammation. However, there are no studies elucidating the relationship between sleep and Klotho. Therefore, this study investigated the association of sleep quantity … " - Biological role of anti-aging protein klotho

Biological role of anti-aging protein klotho

WebKlotho is an anti-aging gene, and mutation of the mouse Klotho gene leads to premature aging syndrome [35]. Klotho protein is expressed predominantly in the kidneys. The expression of Klotho is decreased in the kidneys of not only rat models such as hypertensive rats, {5/6}-nephrectomized rats, and diabetic rats, but also in patients with … WebKlotho is an anti-aging protein with pleiotropic actions that exerts organ protection. Several lines of evidence support the notion that Klotho functions as a human aging-suppression molecule. ... Kałużna-Oleksy …

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WebDec 9, 2024 · Biological Role of Anti-Aging Protein Klotho. Klotho is an anti-aging protein that is mostly detected in the kidney and brain. It was first identified in mice as … WebIntroduction. Klotho, the gene encoding the antiaging protein called klotho, was discovered in 1997 when mice developed multiple organ failure and shortened life span resembling human premature aging after this gene was serendipitously silenced. 1 The klotho-deficient phenotype can be rescued by overexpressing klotho via genetic …

WebApr 10, 2024 · NANOG (Part 1): Its Role In Aging And Cancer. This is the first article in a series on the NANOG protein. Please see my companion series on klotho, another protein that may be involved in aging ... WebMay 1, 2015 · Klotho is an anti-aging single-pass membrane protein predominantly produced in the kidney, with shedding of the amino-terminal extracellular domain into the systemic circulation. Circulating levels of soluble Klotho decrease with age, and the klotho gene is associated with increased risk of age-related diseases.

WebKlotho is an anti-aging factor mainly produced by renal tubular epithelial cells (TEC) with pleiotropic functions. Klotho is down-regulated in acute kidney injury in native kidney; … WebApr 8, 2024 · We also discuss how lncRNAs regulate stem cell biology, focusing finally on their role in human adult renal stem/progenitor cells, in which the lncRNA HOTAIR prevents them from becoming senescent and supports these cells to secrete high quantities of α-Klotho, an anti-aging protein capable of influencing the surrounding tissues and …

WebMay 1, 2015 · Klotho is an anti-aging single-pass membrane protein predominantly produced in the kidney, with shedding of the amino-terminal extracellular domain into the …

WebThe absence of this protein in knockout mice causes their accelerated aging. 8 Most works describing the functions of Klotho investigate the role of this protein in mechanisms of suppressing various age-related pathologies of the ... Kong ID, Cha SK. Biological role of anti-aging protein Klotho. J Lifestyle Med. 2015;5(1):1. doi:10.15280/jlm ... little amal canterburyWebFeb 1, 2024 · The α-Klotho gene is located on human chromosome 13 and contains five exons [1, 2] and encodes a single-pass type I transmembrane protein with three domains: a short intracellular domain (~60 amino acids), a transmembrane domain, and a large extracellular domain (~950 amino acids).As an anti-aging protein, α-Klotho is widely … little amal in nyWebNov 19, 2013 · The Klotho gene was identified as an ‘aging suppressor' in mice. Overexpression of the Klotho gene extends lifespan and defective Klotho results in rapid aging and early death. Both the membrane and secreted forms of Klotho have biological activity that include regulatory effects on general metabolism and a more specific effect … little amal in brooklynWebMar 17, 2024 · Klotho, an anti-aging protein expressed in the distal convoluted tubules ... Biological variability and analytical issues account at least partly for this inconsistency. ... Cheng, C.Y.; Kuro-o, M. Role of Klotho in aging, phosphate metabolism, and CKD. Am. J. Kidney Dis. 2011, 58, 127–134. [Google Scholar] ... little amal in oxfordWebApr 12, 2024 · Previously, we found that an anti-aging protein β-Klotho could significantly improve the proliferation of healthy and diabetic human ADSCs [32]. Most studies … little amal mexicoWeb2012). The systemic effects of Klotho protein appear to be primarily due to its circulating form of secreted soluble Klotho protein, which operates as a humoral factor (Chang et … little amal route sheffieldWebMar 1, 2015 · The structure and function of Klotho, an anti-aging single-pass membrane protein predominantly produced in the kidney, is provided, with shedding of the amino … little amal route