Chir99021 wnt通路
http://www.maokangbio.com/productView.action?id=7957 WebCHIR-99021(也称 CT-99021)是糖原合成酶激酶-3β (GSK-3β) 和 GSK-3α 的有效选择性抑制剂,IC 50 值分别为 6.7 nM 和 10 nM。. 这种小化合 …
Chir99021 wnt通路
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Webmapk信号通路 离子通道 代谢 微生物学 神经科学 nf-κb信号通路 氧化还原 pi3k/akt/mtor信号通路 蛋白酶体 干细胞 蛋白酪氨酸激酶 泛素化 WebCHIR99021 是Wnt/β-catenin信号通路激活剂,还是一种选择性GSK-3α/β抑制剂,IC50为 10 nM 和 6.7 nM。它对GSK-3的选择性比 CDC2、ERK2 和 ...
WebBackground. CHIR-99021 is a highly specific glycogen synthase kinase-3 (GSK-3) inhibitor which can inhibit both isoforms with IC50 of 10 nM (GSK-3α) and 6.7 nM (GSK-3β). … WebCHIR99021 promotes self-renewal of mouse embryonic stem cells by modulation of protein-encoding gene and long intergenic non-coding RNA expression. Experimental cell …
WebAug 27, 2024 · CHIR99021 synergistically increased expression of DP signature genes in combination with floating drop culture. "Reconstituted skin assay" prepared using the … WebSep 30, 2024 · In this study, the availability of CHIR99021 as a potent and cell-permeable Wnt agonist provided the opportunity to assess the degree to which the disease was a result of general depletion of Wnt ...
WebSep 28, 2024 · 虽然不 同物种来源的肠道干细胞对生长因子的需求不同,但 均体现对Wnt等信号的依赖,揭示维持干细胞驱动肠 上皮组织更新所需的固有微环境组分[6-8] 。 ... 与之类似,在Wnt3a CM中添加R-spondin 1、Noggin、 SB202490、CHIR99021(GSK3 抑 制 剂)和 Y27632 (ROCK-Ⅰ和ROCK-Ⅱ ...
WebCHIR-99021 is a GSK-3α/β inhibitor (IC50: 10/6.7 nM). Targets&IC50. GSK-3β:6.7 nM (cell free), GSK-3α:10 nM (cell free) In vitro. CHIR 99021 inhibited human GSK-3β (Ki: 9.8 … ipms cleveland showWebSep 6, 2024 · 肠道类器官培养基的关键成分包括 Wnt-3a (W)、表皮生长因子 (EGF) (E)、Noggin (N) 和 R-spondin-1 (R),统称为 WENR 培养基。. 在培养基中有序地添加这些生 … orbea electric bikes 2020Web目录号 产品名称 中文名称 靶点; M4839: Cell Counting Kit-8: CCK-8试剂盒: Cell Proliferation: CCK试剂盒(Cell Counting Kit),为MTT 法的替代方法,是一种基于WST(水溶性四唑盐,化学名:2-(2-甲氧基-4-硝苯基)-3-(4-硝苯基)-5-(2,4-二磺基苯)-2H-四唑单钠盐)的广泛应用于细胞增殖和细胞毒性的快速高灵敏度检测试剂盒。 orbea electric mountain bikes ukWebCHIR99021 promotes self-renewal of ESCs by modulating transforming growth factor β (TGF-β), Notch and mitogen-activated protein kinases (MAPK) signaling pathways. CHIR99021 is an agonist of wingless/integrated (wnt) signalling, upregulates cyclinA expression and promotes cell proliferation in non-small-cell lung cancer (NSCLC) cell lines. orbea f40 gainWeb在另一项研究中,体外诱导分化后的sheds移植也显著恢复了pd小鼠模型的运动障碍。值得注意的是,研究人员在神经诱导中期向培养基中添加小分子chiR99021,它可以抑制gsk3β激活的细胞的wnt信号通路,从而增加黑质纹状体多巴胺能神经元祖细胞的产生。 orbea ernsthofenipms clinicWeb购买Abcam CHIR99021,GSK3抑制剂(CAS 252917-06-9) (ab120890),纯度> 98%,分子式C22H18Cl2N8,Potent,highly selective GSK3抑制剂。9篇文献引用, ... 细胞信号转导通路. ... Dole NS et al. Mechanosensitive miR-100 coordinates TGFβ and Wnt signaling in osteocytes during fluid shear stress. FASEB J 35:e21883 (2024 ... ipms cleveland