Cisplatin induced hyponatremia

Author: pkyg

August undefined, 2024

WebApr 6, 2024 · Treatment-related grade 3/4 hyponatremia was reported in 5%–7% of MIBC patients treated with pre-operative ... NAC and prolonged survival. 34-36 It is hypothesized that these mutations may increase the sensitivity of tumor cells to cisplatin-induced DNA damage, thereby enhancing the drug's efficacy in these tumors. 37 The incidence of DDR ... WebMar 1, 2024 · A case of an elderly male presenting with significant recurrent hyponatremia, and prerenal azotemia, with recent exposure to cisplatin along with significant hypovolemia and urinary loss of sodium is reported. Cisplatin is a well‐known chemotherapeutic agent that can be associated with hyponatremia. It is known to be associated with a multitude …

Renal Salt-Wasting Syndrome in a Patient With Cisplatin-Indu

WebHyponatremia after chemotherapy is not an uncommon clinical syndrome. Both renal salt-wasting syndrome (RSWS) and syndrome of inappropriate antidiuretic hormone … WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose … dundurn elementary school

Managing Severe Dysgeusia and Dysosmia in Lung Cancer …

WebThe syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a condition characterized by hypotonic and euvolemic hyponatremia along with urinary hyperosmolarity, resulting from antidiuretic hormone (ADH) release in the absence of adequate stimuli. This term was first used in 1957, when Schwartz et al described … WebJul 8, 2010 · Cisplatin based therapy for the treatment of solid organ tumors is commonly associated with several renal abnormalities including; *hypokalemia. * hypomagnesemia. … WebHyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) or gastrointestinal loss of sodium is sometimes seen during chemotherapy. However, … dundurn coach house

A Review of Drug-Induced Hyponatremia - ajkd.org

Chapter 5: Electrolyte and Acid Base Disorders in Malignancy

WebJul 1, 2008 · Hyponatremia associated with platinum compounds is described more frequently with cisplatin than with carboplatin. 42, 43 The possible underlying pathophysiological mechanisms by which cisplatin induces hyponatremia are SIADH and renal salt wasting. 44 Cisplatin-induced hyponatremia often is combined with … WebJan 1, 2024 · Univariable analysis revealed a high incidence of hyponatremia in patients receiving cisplatin, three-drug combination regimen, two-drug combination regimen with amrubicin or irinotecan, or high-dose cisplatin (weekly equivalent cisplatin dose ≥20 mg/m2), and in patients with small-cell lung cancer. Conclusion dundurn gas stationWebWe report a rare case of severe hyponatremia due to cisplatin-induced syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in a 74-year-old male with a … dundurn hair art

"WebCisplatin Induced Hearing Loss Model; Noise Induced Hearing Loss Model; In Vitro Research Model . Cochlea Explant Culture; Ototoxicity Evaluation. ... Hyponatremia (Surgery-induced Hyponatremia Model) Leukopenia (Cyclophosphamide-induced Leukopenia Model) Hepatic and Biliary Disorders. " - Cisplatin induced hyponatremia

Cisplatin induced hyponatremia

Profound hyponatremia and dehydration: A case of cisplatin …

WebAug 1, 2002 · We report a case of a patient with hyponatremia and excessive urinary excretion of sodium after cisplatin-based chemotherapy. RSWS was diagnosed and the patient was treated with a sodium supplement. We also summarize the key diagnostic features and the most common differential diagnoses for hyponatremia syndrome. WebJun 11, 2024 · Concurrent hypoxemia, which may result from noncardiogenic pulmonary edema or hypoventilation, can exacerbate hyponatremia-induced cerebral edema and lead to a vicious cycle ending in death . Impending herniation can be successfully reversed with a 4 to 6 mEq/L increase in the serum sodium concentration . In contrast to the clinical …

Did you know?

WebDec 21, 2024 · Inamori M, Inohara H, Horii A. Diﬀerential diagnosis of hyponatremia induced by cisplatin-con taining chemotherapy: syndrome of inappropriate secretion of an tidiuretic hormone (SIADH) or renal ... WebThe possibility of Cisplatin induced renal salt wasting was considered. The patient was started on Fludrocortisone 0.1mg twice daily, oral salt tablets 1g QID, sodium bicarbonate tablets 650mg TID and normal saline at 150ml/h. ... PROFOUND HYPONATREMIA AND DEHYDRATION: A CASE OF CISPLATIN INDUCED SALT LOSING NEPHROPATHY. …

WebAug 1, 2002 · We report a case of a patient with hyponatremia and excessive urinary excretion of sodium after cisplatin-based chemotherapy. RSWS was diagnosed and the … WebPhysicians may not always give proper attention in time to undesirable drug-induced hyponatremia. Effective clinical management can be handled through awareness of the adverse effect of certain ... Platinum compounds (cisplatin, carboplatin)42-44 Alkylating agents (intravenous cyclophosphamide,45-47 melphalan,48 ifosfamide49)

WebAug 18, 2024 · Volume expansion and dilutional hyponatremia, without neurologic symptoms, can also be induced when isotonic mannitol is used as a flushing solution during transurethral resection of the prostate or bladder. (See "Hyponatremia following transurethral resection, hysteroscopy, or other procedures involving electrolyte-free … WebAbstract We report a rare case of cisplatin-induced acute hyponatremia leading to a seizure and coma. A 66-year-old woman with breast cancer received adjuvant chemotherapy with docetaxel and cisplatin. She had no nausea, vomiting, or diarrhea during or after chemotherapy administration.

WebFluid restriction is the hallmark of SIADH treatment, while increased sodium intake remains the hallmark of RSWS treatment. 6 This patient presented with a combination of cisplatin-induced acute kidney injury (AKI) and …

WebFeb 1, 2016 · The marked urinary losses of sodium in combination with a negative sodium balance led to the diagnosis of cisplatin-induced renal salt wasting syndrome (RSWS). The subsequent clinical... dundurn castle hamilton ontario canadaWebApr 12, 2024 · At the same time, hyponatremia should be related to brain and adrenal metastasis, paraneoplastic syndrome, ... In this case, the standard approach to avoid cisplatin-induced nephrotoxicity and the consequent electrolyte alteration is the administration of IV isotonic saline solution in order to stimulate the diuresis. Some … dundurn hutterite colonyWebMar 1, 2024 · Cisplatin is a well‐known chemotherapeutic agent that can be associated with hyponatremia. It is known to be associated with a multitude of renal disorders including … dundurn lofts rentWebJan 13, 2024 · In addition, significant hyponatremia signals were detected for oesophageal, lung, and renal cancers. Conclusions: Hyponatremia has been reported in women and patients with lung cancer... dundurn legal clinic hamiltonWebNational Center for Biotechnology Information dundurn hillfortWebDec 16, 2024 · Cisplatin induces acute ischemic injury, resulting in decreased renal medullary blood flow ( 24) and renal tubular cell damage ( 25 ). Meanwhile, cisplatin can block calcium ion channels to reduce COX-2 and prostaglandin, cause vasoconstriction, and eventually lead to aggravation of hypoxia ( 26 ). dundurn lofts hamiltonWebElectrolyte disorders with platinum-based chemotherapy: mechanisms, manifestations and management. Platinum chemotherapy, particularly cisplatin, is commonly associated with … dundurn medical group