Cisplatin potassium wasting

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August undefined, 2024

WebApr 7, 2015 · Cisplatin-associated acute kidney injury (AKI) occurred in 8% of the patients. Urine neutrophil gelatinase-associated lipocalin to urine creatinine ratio (NGAL/Cr) and urinary magnesium and potassium wasting increased significantly after cisplatin infusion in … WebCisplatin Foscarnet Aminoglycosides: Laxatives/enemas Sodium polystyrene sulfonate: ... Renal potassium wasting is indicated by a 24-hour urine potassium level exceeding 15 to 30 mEq per L.

Renal salt wasting in patients treated with high-dose cisplatin ...

WebJul 2, 1992 · Cisplatin has many toxic effects; emesis, impairment of renal function, myelosuppression, peripheral neuropathy, ototoxicity and renal tubular wasting. We used MVP regimen (Mitomycin C, Vp-16, and Cisplatin) in advanced Non-Small Cell Lung Cancer (NSCLC). WebCisplatin for injection is a highly emetogenic antineoplastic agent; premedicate with anti-emetic agents; without antiemetic therapy, marked nausea and vomiting occur in almost … can garlic and fish oil be taken together

Cisplatin Nephrotoxicity: A Review - Neil Kurtzman

WebClinical implications of potassium depletion Protective effect of potassium Hypokalemia Potassium supplementation strategies: prevention vs repletion Compliance issues and potassium replacement therapy Potassium repletion and the role of magnesium Consensus guidelines for the use of potassium replacement in clinical practice Article … Webwasting due to cisplatin therapy. Although patients with cancer have hyponatremia due to many etiologies (Table 1), SIADH is the most common etiol-ogy that is directly … WebFeb 5, 2014 · Cisplatin is one of the most potent and valuable chemotherapy agents available, and is used to treat a broad spectrum of malignancies, with cisplatin … fitbit release date history

Hyperkalemia (High Potassium) - Managing Side Effects - Chemocare

Hypomagnesemia and renal magnesium wasting in patients …

WebJul 22, 2024 · Exposure of tubular cells to cisplatin activates complex signaling pathways that result in tubular cell injury and cell death. A robust inflammatory response, as well as … WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin … can garlic and lettuce be planted togetherWebJan 12, 2024 · A missense mutation in the Kv1.1 voltage-gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia. J Clin … can garlic and strawberries be grown together

"WebAug 16, 2024 · Cisplatin-associated electrolyte dysregulation is a prevalent therapy-related adverse effect. There are numerous electrolyte-supplemented hydration regimens that have been evaluated, however these studies focused on the development of nephrotoxicity. " - Cisplatin potassium wasting

Cisplatin potassium wasting

Cisplatin-Induced Acute Kidney Injury and Renal Salt Wasting …

WebCisplatin is known to induce Fanconi syndrome and renal salt wasting (RSW). RSW typically only requires transient normal saline (NS) support. We report a severe RSW case that required 12 liters of 3% saline. A 57-year-old woman with limited stage small cell cancer was admitted for cisplatin (80 mg/m 2) and etoposide (100 mg/m 2) therapy. WebNational Center for Biotechnology Information

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WebThe urinary potassium excretion of a patient with hypokalemia is lowered to less than 25 mEq/day. 35 A value above this suggests at least a component of renal potassium wasting. Because 24-hour urine collections are often impractical, a spot urine potassium may be performed. WebCisplatin induces hypomagnesemia through its renal toxicity possibly by a direct injury to mechanisms of magnesium reabsorption in the ascending limb of the loop of Henle …

WebApr 7, 2015 · Cisplatin-associated acute kidney injury (AKI) occurred in 8% of the patients. Urine neutrophil gelatinase-associated lipocalin to urine creatinine ratio (NGAL/Cr) and …

WebCisplatin (cis-diamminedichloroplatinum II), a chemotherapeutic agent used against epithelial neoplasms, is known to cause hypomagnesemia and renal magnesium wasting. In order to further characterize the effect of multiple doses of this drug upon serum magnesium levels and renal magnesium handling, … WebHyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) or gastrointestinal loss of sodium is sometimes seen during chemotherapy. However, …

WebCisplatin was the first platinum compound to be introduced as a chemotherapeutic agent with antineoplastic activity against a wide variety of solid tumors. Renal …

WebCDDP-induced hyponatremia has also occurred in a case of renal salt-wasting syndrome, 4 in patients with nausea/vomiting/anorexia, and when vigorous hydration was administered to prevent nephrotoxicity. 5 It is sometimes difficult to accurately diagnose the cause of hyponatremia because various contributing factors can interact in a complex manner. fitbit releaseWebRefractory Potassium Repletion due to Cisplatin-Induced Magnesium Depletion JAMA Internal Medicine JAMA Network • Cisplatin is a common cause of hypomagnesemia … fitbit relax low alignmentWebJul 18, 2024 · In fact, Schilsky and colleagues showed that 22 of 29 patients (76%) who received cisplatin for non-seminomatous germ cell tumors developed acute hypomagnesemia; eleven (50%) remained hypomagnesemic for at least 3 years. 83 This long-term effect has been corroborated by other investigators as well. 84, 85 can garlic and onions grow togetherWebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … fitbit release scheduleWebis an uncommon genetic disorder characterized by renal potassium and sodium wasting, excessive production of renin and aldosterone, and normotension. Gitelman syndrome is caused by loss of function mutations in a thiazide-sensitive ion … can garlic be bad for youWebMay 24, 2006 · Cisplatin is a well-known nephrotoxic antineoplastic drug. Chronic hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria is one of the … can garlic be compostedWebJul 18, 2024 · Cisplatin may cause hypomagnesemia by downregulating the TRPM6/EGF pathway. Of note, Mg co‐administration mitigates both cisplatin‐induced … can garlic be dehydrated