WebNov 28, 2024 · Consequently, FLS2 is ubiquitinated by PUB12/PUB13 and then degraded through a 26S proteasome pathway. In a similar manner, rice PRR Xa21 is negatively regulated by the protein phosphatase 2C and ubiquitinated by the RING-finger ubiquitin E3 ligase XB3 . However, in contrast to PUB12/PUB13, XB3 positively regulates Xa21 … WebOct 21, 2024 · PUB13 is an active E3 ubiquitin ligase and that the intact U-box domain is required for the E3 ligase activity. study has revealed a unique regulatory circuit of direct ubiquitination and turnover of FLS2 by BAK1-mediated phosphorylation and recruitment of specific E3 ligases (PUB12,PUB13) for attenuation of immune signaling
Function of PUB12 and PUB13 in FLS2 signaling. (A) …
WebFeb 20, 2014 · FLS2 is ubiquitinated by two closely related plant U-box E3 ubiquitin ligases, PUB12 and PUB13, and subjected to degradation (Lu et al ., 2011 ). PUB12 and PUB13 interact with BAK1, and are recruited to FLS2 on flg22 perception. BAK1 phosphorylates PUB12 and PUB13 directly, and is required for FLS2 and PUB12/13 association. WebOct 21, 2024 · Encodes a U-box E3 ubiquitin ligase involved in ubiquitination of pattern recognition receptor FLS2. NEW Try the new Gene table Try the new Transcript table. … cisco webex meetings free download windows 10
Ubiquitin signalling: controlling the message of surface immune ...
http://biochemistry.tamu.edu/wp-content/uploads/sites/104/2016/03/FLS2_Ubiq_Science_2011.pdf WebApr 18, 2013 · Author Summary As a Pattern-Recognition Receptor (PRR) that detects conserved microbial molecules, FLS2 mediates the plant innate immunity responses … WebPUB12 and PUB13 are recruited to the FLS2 complex in response to flg22 (Lu et al., 2011). BAK1 phosphorylation of PUB12/PUB13 leads to FLS2 ubiquitination by the E3 ligases for receptor degradation. Consistent with this, FLS2 signaling outputs and bacterial resistance are enhanced in pub12 pub13 plants. Following ligand-induced association diamond star motors plant