WebApr 12, 2024 · Atea will also present clinical data for AT-752, an oral double prodrug of a guanosine nucleotide analog for the treatment of dengue virus, at ECCMID 2024. As part of a Phase 1 single and multiple ascending dose study, which evaluated the safety, tolerability and pharmacokinetics of AT-752, a concentration-QTc (C-QTc) analysis was conducted. WebNov 22, 2010 · A prodrug actually has several biopharmaceutical benifits. First of all, it is important to understand the definition of a prodrug. A prodrug is a drug that is taken inactive, and through natural ...
BASIC CONCEPTS AND APPLICATION OF PRODRUG …
WebJan 1, 2024 · Prodrugs, Fig. 1 A simplified representation of the prodrug concept. The drug-promoiety molecule is the prodrug that is inactive or very weakly active pharmacologically. In broad terms, the barrier can be thought of as any liability for a parent drug that prevents its optimal pharmaceutical or pharmacological performance Full size image WebAn active metabolite results when a drug is metabolized by the body into a modified form which produces effects in the body. Usually these effects are similar to those of the parent drug but weaker, [citation needed] although they can still be significant (see e.g. 11-hydroxy-THC, morphine-6-glucuronide ). my throat feels clogged with mucus
Prodrug - Wikipedia
Webnoun. Any of various drugs that are administered in an inactive form and converted into active form by normal metabolic processes. American Heritage Medicine. Similar … Webprodrug sofpironium therapeutic index toxic metabolite 1. Introduction Soft drugs (SDs) are therapeutically active compounds that undergo a predicted fast metabolism into inactive metabolites after exerting their desired therapeutic effects. WebProdrug definition: A chemical with little or no pharmacologic activity that undergoes change in the body into a more active material. The change may be a result of … my throat feels hot