WebPhenobarbital was administered once as a CYP inducer in the carbon tetrachloride-induced hepatitis model mice. The mRNA expression levels of Cyp3a11 and Cyp2b10 in the liver and small intestine were measured using reverse transcription polymerase chain reaction. The enzymatic activity of CYP3A in liver S9 was evaluated using midazolam as the ... Status epilepticus: Infants, Children, and Adolescents: IV: Initial: 15-20 mg/kg; maximum dose: 1000 mg; may repeat once after 10-15 minutes if needed; maximum total dose: 40 mg/kg; repeat doses administered sooner than 10-15 minutes may not allow adequate time for peak CNS concentrations to be achieved … See more Sedation: Oral, IV, IM: 30 to 120 mg/day in 2 to 3 divided doses; maximum: 400 mg/day Preoperative sedation: IM: 100 to 200 mg 60 to 90 minutes before surgery Status epilepticus:IV: … See more An alcohol-free 10 mg/mL phenobarbital oral suspension may be made from tablets and one of two different vehicles (a 1:1 mixture of Ora-Plus and Ora-Sweet or a 1:1 mixture of Ora-Plus … See more May be administered IV, IM, or orally. According to the manufacturer, rapid IV administration >60 mg/minute should be avoided. In the setting of status epilepticus, the Neurocritical Care Society recommends … See more
Phenobarbital (IARC Summary & Evaluation, Volume 79, 2001)
WebPhenobarbital, which induces hepatic metabolism, decreased the AUC of Montelukast approximately 40% following a single 10mg dose of Montelukast. No dosage adjustment for Montelukast is recommended. It is reasonable to employ appropriate clinical monitoring when potent cytochrome P450 enzyme inducers, such as phenobarbital or rifampin, are … WebMar 27, 2024 · Phenobarbital is a well-established inducer of the cytochrome P450 enzymes 3A4 and 2B6 , hepatic metabolism pathways for hundreds of common medications. PB … phoenix moss adams
Phenobarbital: Uses, Interactions, Mechanism of Action
WebFeb 17, 2024 · Includes PHENobarbital indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse ... WebAug 25, 2024 · 20–320 mg; repeat in 6 hours, if necessary. Alternatively, 200–600 mg; allow up to 30 minutes for maximum anticonvulsant effect before administering additional … WebMar 1, 2024 · Each mL contains phenobarbital sodium either 65 mg or 130 mg, alcohol 0.1 mL, and propylene glycol 0.678 mL in Water for Injection; hydrochloric acid added, if needed, for pH adjustment. The pH range is 9.2-10.2. Contains no preservative. Chemically, phenobarbital sodium is 2,4,6 (1 H ,3 H ,5 H )-Pyrimidinetrione,5-ethyl-5-phenyl-, … phoenix motorcycle fatality today