WebJan 17, 2024 · Nat Commun: 表型研究发现SRC诱导转化的关键介质—SGK1. 编者按：SRC蛋白是非受体酪氨酸激酶，可被多条信号转导途径所激活。. 今天解读的这篇文章最近发表 … WebJan 29, 2024 · 邹伟平课题组揭示肿瘤STC1蛋白参与免疫治疗耐受的机制. 北京时间2024年1月29日，美国 密歇根大学 医学院 邹伟平 课题组在《癌细胞》发表论 …
受体相互作用蛋白1泛素化调控的研究进展 - 上海商业杂志社
Sic1, a protein, is a stoichiometric inhibitor of Cdk1-Clb (B-type cyclins) complexes in the budding yeast Saccharomyces cerevisiae. Because B-type cyclin-Cdk1 complexes are the drivers of S-phase initiation, Sic1 prevents premature S-phase entry. Multisite phosphorylation of Sic1 is thought to time Sic1 … See more In the G1 phase of the cell cycle, Sic1 binds tightly to the Cdc28-Clb complex and inhibits it. Low Cdc28-Clb activity leads to the disassembly of the mitotic spindle, the assembly of the prereplicative complex and initiation of See more Sic1 needs to be phosphorylated at multiple sites for ubiquitination-driven degradation (Fig. 2). The multiple phosphorylations are required for Sic1 to … See more • p27 • CDKN1B See more • Page of Sic1 at yeastgenome.org See more In order to be recognized by Cdc4 of the SCF complex, Sic1 has to be phosphorylated, often by Cyclin-Cdk complexes, at least at 6 of the 9 cdk sites (Fig. 2). Sic1 can also be phosphorylated by other kinases, such as Pho85-Pc11, a kinase which … See more The protein p27Kip1 is a human homologue of Sic1, both having a conserved inhibitory domain, but p27Kip1 inhibits G1 cyclins and not cyclin B. There are several human diseases that are linked to p27Kip1 and other cyclin kinase inhibitors: See more http://www.qiyuebio.com/details/29769 ipc class 3 ds
视频！邹伟平课题组揭示肿瘤STC1蛋白参与免疫治疗耐受的机制
WebFeb 1, 2000 · 单位：军事医学科学院微生物流行病研究所，北京 100071. 关键词：人类免疫缺陷病毒Ⅰ型 (HIV-1)；p24蛋白；基因表达；大肠杆菌. 中国病毒学000204 摘要：合成引 … WebFeb 10, 2024 · 在分析了1000多个基因之后，密歇根大学（U-M）Rogel癌症中心的研究人员发现，这种糖蛋白也可能成为癌症免疫疗法的障碍。 他们的研究结果发表在《Cancer Cell》杂志上一篇题为“Stanniocalcin 1 is a … Web生长层,growth layer 1)growth layer生长层 1.It is found that the main defects are ferroelastic domains, antiphase domains, growth layers, growth sectors and dislocations.这些缺陷是铁弹畴、反相畴界、生长层和生长区界面，探讨了它们的成因及其克服办 2.The suitable ion bombardment conditions were obtained by investigation of growth layer of ZnO,which … ipc class a b c