WebbThe zebrafish has recently emerged as a powerful vertebrate model system to study hematopoiesis. The developmental processes and molecular mechanisms involved in zebrafish hematopoiesis are conserved with higher vertebrates, and the genetic and experimental accessibility of the fish and the optical transparency of its embryos and … Webb15 sep. 2007 · Janus kinase 2 (Jak2) transduces signals from hematopoietic cytokines, and a gain-of-function mutation (Jak2 617V>F) is associated with myeloproliferative …
30307 - Gene Resultjak2a Janus kinase 2a [ (zebrafish)]
Webb19 feb. 2024 · Recently, mutations in the gene encoding ribosomal protein (RP) L18 were identified in DBA patients. RPL18 is a crucial component of the ribosomal large subunit but its role in hematopoiesis remains unknown. To genetically model the ribosomal defect identified in DBA, we generated a rpl18 mutant line in zebrafish, using CRISPR/Cas9 … WebbThe role of jak2a in zebrafish hematopoiesis. Authors: Ma AC, Ward AC, Liang R, Leung AY. Citation: Blood. 2007 Sep 15;110(6):1824-30. Epub 2007 Jun 1 ... towneplace battle creek
The role of stat1b in zebrafish hematopoiesis - PMC
Webb14 sep. 2007 · In this study, we examined the role of jak2a in zebrafish embryos in knock-down and overexpression studies using morpholinos (MOs) targeting the 5\u27 untranslated region (UTR) (jak2aUTR-MO) and splice-site junction (jak2aSS-MO) of jak2a, a Jak inhibitor AG490 and a constitutive-active form of jak2a (jak2aca). Webb14 sep. 2007 · In this study, we examined the role of jak2a in zebrafish embryos in knock-down and overexpression studies using morpholinos (MOs) targeting the 5\u27 … Webb23 dec. 2010 · The mutated-JAK2 nuclear translocation is mainly reverted by the addiction of the JAK2 inhibitor AG490. Methods Cell cultures K562 were grown as previously described. 8 Transfection was performed by AMAXA electroporation, and stable cell lines were obtained by puromycin selection (3 μg/mL). towneplace baltimore